Selected Publications

 

  • Veeraraghavan P, Engmann AK, Hatch JJ, Itoh Y,  Nguyen D, Addison T, Macklis JD. Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of neocortical projection neurons. bioRxiv 2023 Sept 24. doi:https://doi.org/10.1101/2023.09.24.559186

 

  • Greig LC, Woodworth MB, Poulopoulos A, Lim S, Macklis JD. BEAM: a combinatorial recombinase toolbox for binary gene expression and mosaic analysis. bioRxiv [Preprint]. 2023 Feb 16:2023.02.16.528875. doi: 10.1101/2023.02.16.528875. PMCID: PMC9949094.

 

  • Durak, O*, Kim, JY*, Tillman, DE, Itoh, Y, Wettstein, M, Greig, LC, Macklis, JD. ASD gene Bcl11a regulates subcellular RNA localization, associative circuitry, and social behavior. bioRxiv 2022; DOI: https://doi.org/10.1101/2022.10.06.511159 

 

  • Froberg JE, Durak O, Macklis JD. Development of nanoRibo-seq enables study of regulated translation by cortical neuron subtypes, showing uORF translation in synaptic-axonal genes. Cell Rep. 2023 Sep 26;42(9):112995. doi: 10.1016/j.celrep.2023.112995. Epub 2023 Aug 24. PMID: 37624698; PMCID: PMC10591829

 

  • Galazo MJ, Sweetser DA, Macklis JD. Tle4 controls both developmental acquisition and early postnatal maturation of corticothalamic projection neuron identity. Cell Rep. 2023; Aug 29;42(8):112957. doi: 10.1016/j.celrep.2023.112957. PMCID: PMC10542749. 

 

  • Itoh Y*, Sahni V*, Shnider SJ, McKee H, Macklis JD. Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations. Cell Rep. 2023 Mar 28;42(3):112182. PMC10167627 DOI: 10.1016/j.celrep.2023.112182 

 

  • Song JHT, Ruven C, Patel P, Ding F, Macklis JD*, Sahni V*. Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord. J Neurosci. 2023; Mar 15; 43 (11): 1871-1887. PMC10027075 DOI: 10.1523/JNEUROSCI.0710-22.2023 

 

  • Engmann AK, Hatch JJ, Nanda P, Veeraraghavan P, Ozkan A, Poulopoulos A, Murphy AJ, Macklis JD. 2022. Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes. Nature protocols. 17(2):222-251. PUBMED: 35022617 DOI:10.1038/S41596-021-00638-7

 

  • Sahni V, Shnider SJ, Jabaudon D, Song JHT, Itoh Y, Greig LC, Macklis JD. 2021. Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting. Cell reports. 37(3):109843. PUBMED: 34686320 DOI:10.1016/J.CELREP.2021.109843

 

  • Sahni V, Itoh Y, Shnider SJ, Macklis JD. 2021. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting. Cell reports. 37(3):109842. PUBMED: 34686337 DOI:10.1016/J.CELREP.2021.109842

 

  • Diaz JL, Siththanandan VB, Lu V, Gonzalez-Nava N, Pasquina L, MacDonald JL, Woodworth MB, Ozkan A, Nair R, He Z, Sahni V, Sarnow P, Palmer TD, Macklis JD, Tharin S. 2020. An evolutionarily acquired microRNA shapes development of mammalian cortical projections. Proceedings of the National Academy of Sciences of the United States of America. 117(46):29113-29122. PUBMED: 33139574 DOI:10.1073/PNAS.2006700117

 

  • Poulopoulos A, Murphy AJ, Ozkan A, Davis P, Hatch J, Kirchner R, Macklis JD. 2019. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex. Nature. 565(7739):356-360. PUBMED: 30626971 DOI:10.1038/S41586-018-0847-Y

 

  • Wuttke TV, Markopoulos F, Padmanabhan H, Wheeler AP, Murthy VN, Macklis JD. 2018. Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation. Nature neuroscience. 21(4):517-529. PUBMED: 29507412 DOI:10.1038/S41593-018-0098-0

 

  • Galazo MJ, Emsley JG, Macklis JD. 2016. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 91(1):90-106. PUBMED: 27321927 DOI:S0896-6273(16)30203-3

 

  • Greig LC, Woodworth MB, Greppi C, Macklis JD. 2016. Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 90(2):261-77. PUBMED: 27100196 DOI:S0896-6273(16)00187-2

 

  • Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD. 2016.  Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell rep. 2016 May 3;15(5):999-1012. PUBMED: 4873759 DOI: 10.1016/j.celrep.2016.03.064

 

  • Greig LC, Woodworth MB, Galazo MJ, Padmanabhan H, Macklis JD. 2013. Molecular logic of neocortical projection neuron specification, development and diversity. Nature reviews. Neuroscience. 14(11):755-69. PUBMED: 24105342 DOI:10.1038/NRN3586

 

  • Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. 2011. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science (New York, N.Y.). 334(6059):1133-7. PUBMED: 22116886 DOI:10.1126/SCIENCE.1209870