Scientists have identified a gene in mice that plays a central role in the proper development of one of the nerve cells that goes bad in amyotrophic lateral sclerosis, or Lou Gehrig's disease, and some other diseases that affect our motor neurons.

 

The study is the result of a collaboration by scientists at the University of Rochester Medical Center who normally focus on the eye, working together with a developmental neuroscientist at Harvard who focuses on the cerebral cortex. The work appears in the Oct. 23 issue of the journal Neuron.

The work centers on corticospinal neurons, crucial nerve cells that connect the brain to the spinal cord. These neurons degenerate in patients with ALS, and their injury can play a central role in spinal cord injury as well. These are the longest nerves in the central nervous system – nerves sometimes several feet long that run from the brain to the spinal cord. As the ends of the nerves degenerate, patients lose the ability to control their muscles.

The team led by Lin Gan, Ph.D., of Rochester and Jeffrey D. Macklis, M.D., D.HST, of Harvard showed that a protein known as Bhlhb5 is central to how the brain's progenitor cells ultimately become corticospinal motor neurons, one type of neuron that deteriorates in ALS. The same group of neurons also degenerates in patients with a rare neurological disease known as hereditary spastic paraplegia.

The work by the Harvard and Rochester scientists marks an important step in scientists' understanding of how stem cells in the brain eventually grow into the extraordinary network of circuits that make up the human nervous system. Understanding how the body determines the destiny of stem and progenitor cells is crucial if physicians are to ultimately use the cells to create new treatments for motor neuron diseases like ALS and HSP, as well as other conditions such as Parkinson's and Huntington's diseases and spinal cord injury.

Macklis' team is a world leader in discovering how the brain determines the destiny of its cells. The process is a bit like what happens on a construction site, where a foreman taps the expertise of a variety of workers – carpenters, plumbers, bricklayers, and so on – as needed to build a given structure. In the brain, teams of molecular signaling molecules are brought together to create nerve cells out of raw material where and when needed. Hundreds of such signaling molecules are brought together instantly and continually to allow the brain to create the nerve cells it needs for growth and development.

"How does the brain take a broad class of neurons and decide which ones to send to the spinal cord, or which will connect to our visual centers?" said Macklis, who is director of the Center for Nervous System Repair at Massachusetts General Hospital and at Harvard.

"We're looking at how the most sophisticated portion of the brain, the neocortex, creates the right kind of neurons where and when they're needed. Understanding how our brain circuits are initially built is the first step to repairing or reversing many diseases of the nervous system," added Macklis.

The team showed that the molecular interactions that help control the destiny of the brain's progenitor cells can take place a bit later than some scientists have considered. The team found that Bhlhb5 plays an important role in determining the fate of progenitor cells that that have already exited the cell cycle and are well on their way to being refined into more precise types of cells.

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